AustralieFrV1, Main, Exploration, bibRecord, 00A494

Prediction of BRCA1 status in patients with breast cancer using estroqen receptor and basal phenotype

Identifieur interne : 00A494 ( Main/Exploration ); précédent : 00A493; suivant : 00A495

Prediction of BRCA1 status in patients with breast cancer using estroqen receptor and basal phenotype

Auteurs : Sunil R. Lakhani [Royaume-Uni, Australie] ; Jorge S. Reis-Filho [Royaume-Uni] ; Laura Fulford [Royaume-Uni] ; Frederique Penault-Llorca [France] ; Marc Van Dervijver [Pays-Bas] ; Suzanne Parry [Royaume-Uni] ; Timothy Bishop [Royaume-Uni] ; Javier Benitez [Espagne] ; Carmen Rivas [Espagne] ; Yves-Jean Bignon [France] ; Jenny Chang-Claude [Allemagne] ; Ute Hamann [Allemagne] ; Cees J. Cornelisse [Pays-Bas] ; Peter Devilee [Pays-Bas] ; Matthias W. Beckmann [Allemagne] ; Carolin Nestle-Kr Mling [Allemagne] ; Peter A. Daly [Irlande (pays)] ; Neva Haites [Royaume-Uni] ; Jenny Varley [Royaume-Uni] ; Fiona Lalloo [Royaume-Uni] ; Gareth Evans [Royaume-Uni] ; Christine Maugard [France] ; Hanne Meijers-Heijboer [Pays-Bas] ; Jan G. M. Klijn [Pays-Bas] ; Edith Olah [Hongrie] ; Barry A. Gusterson [Royaume-Uni] ; Silvana Pilotti [Italie] ; Paolo Radice [Italie] ; Siegfried Scherneck [Allemagne] ; Hagay Sobol [France] ; Jocelyne Jacquemier [France] ; Teresa Wagner [Autriche] ; Julian Peto [Royaume-Uni] ; Michael R. Stratton [Royaume-Uni] ; Lesley Mcguffog ; Douglas F. Easton

Source :

Clinical cancer research [ 1078-0432 ] ; 2005.

RBID : Pascal:05-0335175

Descripteurs français

Pascal (Inist)
- Prédiction, Facteur prédictif, Gène suppresseur tumeur, Gène BRCA1, Homme, Glande mammaire pathologie, Tumeur maligne, Récepteur biologique, Phénotype, Cancer sein.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- BRCA1 gene, Biological receptor, Breast cancer, Human, Malignant tumor, Mammary gland diseases, Phenotype, Prediction, Predictive factor, Tumor suppressor gene.

Abstract

Purpose:To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients. Experimental Design: Histopathologic material from 182 tumors in BRCA1 mutation carriers, 63 BRCA2 carriers, and 109 controls, collected as part of the international Breast Cancer Linkage Consortium were immunohistochemically stained for CK14, CK5/6, CK17, epidermal growth factor receptor (EGFR), and osteonectin. Results: All five basal markers were commoner in BRCA1 tumors than in control tumors (CK14: 61% versus, 12%; CK5/6: 58% versus 7%; CK17: 53%versus10%; osteonectin: 43%versus19%; EGFR: 67% versus 21%; P < 0.0001 in each case). In a multivariate analysis, CK14, CK5/6, and estrogen receptor (ER) remained significant predictors of BRCA1 carrier status. In contrast, the frequency of basal markers in BRCA2 tumors did not differ significant from controls. Conclusion: The use of cytokeratin staining in combination with ER and morphology provides a more accurate predictor of BRCA1 mutation status than previously available, that may be useful in selecting patients for BRCA1 mutation testing. The high percentage of BRCA1 cases positive for EGFR suggests that specific anti-tyrosine kinase therapy may be of potential benefit in these patients.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name>
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<author><name sortKey="Pilotti, Silvana" sort="Pilotti, Silvana" uniqKey="Pilotti S" first="Silvana" last="Pilotti">Silvana Pilotti</name>
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<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
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<author><name sortKey="Scherneck, Siegfried" sort="Scherneck, Siegfried" uniqKey="Scherneck S" first="Siegfried" last="Scherneck">Siegfried Scherneck</name>
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</inist:fA14>
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<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacquemier, Jocelyne" sort="Jacquemier, Jocelyne" uniqKey="Jacquemier J" first="Jocelyne" last="Jacquemier">Jocelyne Jacquemier</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Genetic Oncology and Cancer Control, Institut National de la Sante et de la Recherche Medicale EPI 9939, Paoli Calmettes Institute</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wagner, Teresa" sort="Wagner, Teresa" uniqKey="Wagner T" first="Teresa" last="Wagner">Teresa Wagner</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Obstetrics and Gynaecology, General Hospital, University of Vienna</s1>
<s3>AUT</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Obstetrics and Gynaecology, General Hospital, University of Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</s1>
<s3>GBR</s3>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</s1>
<s3>GBR</s3>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0335175</idno>
<date when="2005">2005</date>
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<idno type="RBID">Pascal:05-0335175</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">004848</idno>
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<idno type="wicri:doubleKey">1078-0432:2005:Lakhani S:prediction:of:brca</idno>
<idno type="wicri:Area/Main/Merge">00B091</idno>
<idno type="wicri:Area/Main/Curation">00A494</idno>
<idno type="wicri:Area/Main/Exploration">00A494</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prediction of BRCA1 status in patients with breast cancer using estroqen receptor and basal phenotype</title>
<author><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Molecular and Cellular Pathology, University of Queensland</s1>
<s2>Brisbane</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reis Filho, Jorge S" sort="Reis Filho, Jorge S" uniqKey="Reis Filho J" first="Jorge S." last="Reis-Filho">Jorge S. Reis-Filho</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fulford, Laura" sort="Fulford, Laura" uniqKey="Fulford L" first="Laura" last="Fulford">Laura Fulford</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Jean Perrin</s1>
<s2>Clermont-Ferrand</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Dervijver, Marc" sort="Van Dervijver, Marc" uniqKey="Van Dervijver M" first="Marc" last="Van Dervijver">Marc Van Dervijver</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>The Netherlands Cancer Institute</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parry, Suzanne" sort="Parry, Suzanne" uniqKey="Parry S" first="Suzanne" last="Parry">Suzanne Parry</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bishop, Timothy" sort="Bishop, Timothy" uniqKey="Bishop T" first="Timothy" last="Bishop">Timothy Bishop</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Imperial Cancer Research Fund Genetic Epidemiology Laboratory, St. James University Hospital</s1>
<s2>Leeds</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Genetics, Dpto Genetica Humana. Centro Nacional nvestigaciones Oncológicas</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Pathology, Fundación Jiménez Díaz, Autonomous University of Madrid</s1>
<s2>Madrid</s2>
<s3>ESP</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Jean Perrin</s1>
<s2>Clermont-Ferrand</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Auvergne (région administrative)</region>
<settlement type="city">Clermont-Ferrand</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Deutsches Krebsforschungszentrum, Divisions of Epidemiology and Molecular Genome Analysis</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Deutsches Krebsforschungszentrum, Divisions of Epidemiology and Molecular Genome Analysis</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cornelisse, Cees J" sort="Cornelisse, Cees J" uniqKey="Cornelisse C" first="Cees J." last="Cornelisse">Cees J. Cornelisse</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Genetics and Pathology, Leiden University</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Genetics and Pathology, Leiden University</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Departments of Obstetrics and Gynecology, Friedrich Alexander University</s1>
<s2>Erlangen</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nestle Kr Mling, Carolin" sort="Nestle Kr Mling, Carolin" uniqKey="Nestle Kr Mling C" first="Carolin" last="Nestle-Kr Mling">Carolin Nestle-Kr Mling</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Departments of Obstetrics and Gynecology, Friedrich Alexander University</s1>
<s2>Erlangen</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Medicine, Trinity College Medical School, St James Hospital</s1>
<s2>Dublin</s2>
<s3>IRL</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Irlande (pays)</country>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Haites, Neva" sort="Haites, Neva" uniqKey="Haites N" first="Neva" last="Haites">Neva Haites</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Medical Genetics, Department of Medicine and Therapeutics, University of Aberdeen</s1>
<s2>Aberdeen</s2>
<s3>GBR</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Aberdeen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Varley, Jenny" sort="Varley, Jenny" uniqKey="Varley J" first="Jenny" last="Varley">Jenny Varley</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>CRUK Cancer Genetics Group, Paterson Institute for Cancer Research</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Medical Genetics, St. Mary's Hospital</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Evans, Gareth" sort="Evans, Gareth" uniqKey="Evans G" first="Gareth" last="Evans">Gareth Evans</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Medical Genetics, St. Mary's Hospital</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maugard, Christine" sort="Maugard, Christine" uniqKey="Maugard C" first="Christine" last="Maugard">Christine Maugard</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>University Hospital</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Clinical Genetics and Medical Oncology, Daniel den Hoed Cancer Centre, Erasmus University Medical Centre Rotterdam</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Clinical Genetics and Medical Oncology, Daniel den Hoed Cancer Centre, Erasmus University Medical Centre Rotterdam</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Molecular Biology, National Institute of Oncology</s1>
<s2>Budapest</s2>
<s3>HUN</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Hongrie</country>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gusterson, Barry A" sort="Gusterson, Barry A" uniqKey="Gusterson B" first="Barry A." last="Gusterson">Barry A. Gusterson</name>
<affiliation wicri:level="4"><inist:fA14 i1="18"><s1>Department of Pathology, Western Infirmary, University of Glasgow</s1>
<s2>Scotland</s2>
<s3>GBR</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Pilotti, Silvana" sort="Pilotti, Silvana" uniqKey="Pilotti S" first="Silvana" last="Pilotti">Silvana Pilotti</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Pathology, Istituto Nazionale Tumori</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Experimental Oncology, Istituto Nazionale Tumori</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scherneck, Siegfried" sort="Scherneck, Siegfried" uniqKey="Scherneck S" first="Siegfried" last="Scherneck">Siegfried Scherneck</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Max-Delbruck-Centrum fur Moleculare Medizin, Tumorgenetik</s1>
<s2>Berlin</s2>
<s3>DEU</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Genetic Oncology and Cancer Control, Institut National de la Sante et de la Recherche Medicale EPI 9939, Paoli Calmettes Institute</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacquemier, Jocelyne" sort="Jacquemier, Jocelyne" uniqKey="Jacquemier J" first="Jocelyne" last="Jacquemier">Jocelyne Jacquemier</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Genetic Oncology and Cancer Control, Institut National de la Sante et de la Recherche Medicale EPI 9939, Paoli Calmettes Institute</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>30 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wagner, Teresa" sort="Wagner, Teresa" uniqKey="Wagner T" first="Teresa" last="Wagner">Teresa Wagner</name>
<affiliation wicri:level="1"><inist:fA14 i1="23"><s1>Department of Obstetrics and Gynaecology, General Hospital, University of Vienna</s1>
<s3>AUT</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Department of Obstetrics and Gynaecology, General Hospital, University of Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</s1>
<s3>GBR</s3>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>London School of Hygiene and Tropical Medicine</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</s1>
<s3>GBR</s3>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Sections of Cancer Genetics and Epidemiology, Institute of Cancer Research, Haddow Laboratories</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
</author>
</analytic>
<series><title level="j" type="main">Clinical cancer research</title>
<title level="j" type="abbreviated">Clin. cancer res.</title>
<idno type="ISSN">1078-0432</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical cancer research</title>
<title level="j" type="abbreviated">Clin. cancer res.</title>
<idno type="ISSN">1078-0432</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BRCA1 gene</term>
<term>Biological receptor</term>
<term>Breast cancer</term>
<term>Human</term>
<term>Malignant tumor</term>
<term>Mammary gland diseases</term>
<term>Phenotype</term>
<term>Prediction</term>
<term>Predictive factor</term>
<term>Tumor suppressor gene</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Prédiction</term>
<term>Facteur prédictif</term>
<term>Gène suppresseur tumeur</term>
<term>Gène BRCA1</term>
<term>Homme</term>
<term>Glande mammaire pathologie</term>
<term>Tumeur maligne</term>
<term>Récepteur biologique</term>
<term>Phénotype</term>
<term>Cancer sein</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose:To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients. Experimental Design: Histopathologic material from 182 tumors in BRCA1 mutation carriers, 63 BRCA2 carriers, and 109 controls, collected as part of the international Breast Cancer Linkage Consortium were immunohistochemically stained for CK14, CK5/6, CK17, epidermal growth factor receptor (EGFR), and osteonectin. Results: All five basal markers were commoner in BRCA1 tumors than in control tumors (CK14: 61% versus, 12%; CK5/6: 58% versus 7%; CK17: 53%versus10%; osteonectin: 43%versus19%; EGFR: 67% versus 21%; P < 0.0001 in each case). In a multivariate analysis, CK14, CK5/6, and estrogen receptor (ER) remained significant predictors of BRCA1 carrier status. In contrast, the frequency of basal markers in BRCA2 tumors did not differ significant from controls. Conclusion: The use of cytokeratin staining in combination with ER and morphology provides a more accurate predictor of BRCA1 mutation status than previously available, that may be useful in selecting patients for BRCA1 mutation testing. The high percentage of BRCA1 cases positive for EGFR suggests that specific anti-tyrosine kinase therapy may be of potential benefit in these patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Espagne</li>
<li>France</li>
<li>Hongrie</li>
<li>Irlande (pays)</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Berlin</li>
<li>Communauté de Madrid</li>
<li>District de Karlsruhe</li>
<li>District de Moyenne-Franconie</li>
<li>Grand Londres</li>
<li>Grand Manchester</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Hongrie centrale</li>
<li>Lombardie</li>
<li>Pays de la Loire</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Écosse</li>
</region>
<settlement><li>Amsterdam</li>
<li>Berlin</li>
<li>Budapest</li>
<li>Clermont-Ferrand</li>
<li>Erlangen</li>
<li>Glasgow</li>
<li>Heidelberg</li>
<li>Leyde</li>
<li>Londres</li>
<li>Madrid</li>
<li>Manchester</li>
<li>Marseille</li>
<li>Milan</li>
<li>Nantes</li>
<li>Rotterdam</li>
</settlement>
<orgName><li>Université de Glasgow</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
</noCountry>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name>
</region>
<name sortKey="Bishop, Timothy" sort="Bishop, Timothy" uniqKey="Bishop T" first="Timothy" last="Bishop">Timothy Bishop</name>
<name sortKey="Evans, Gareth" sort="Evans, Gareth" uniqKey="Evans G" first="Gareth" last="Evans">Gareth Evans</name>
<name sortKey="Fulford, Laura" sort="Fulford, Laura" uniqKey="Fulford L" first="Laura" last="Fulford">Laura Fulford</name>
<name sortKey="Gusterson, Barry A" sort="Gusterson, Barry A" uniqKey="Gusterson B" first="Barry A." last="Gusterson">Barry A. Gusterson</name>
<name sortKey="Haites, Neva" sort="Haites, Neva" uniqKey="Haites N" first="Neva" last="Haites">Neva Haites</name>
<name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name>
<name sortKey="Parry, Suzanne" sort="Parry, Suzanne" uniqKey="Parry S" first="Suzanne" last="Parry">Suzanne Parry</name>
<name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<name sortKey="Reis Filho, Jorge S" sort="Reis Filho, Jorge S" uniqKey="Reis Filho J" first="Jorge S." last="Reis-Filho">Jorge S. Reis-Filho</name>
<name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name>
<name sortKey="Varley, Jenny" sort="Varley, Jenny" uniqKey="Varley J" first="Jenny" last="Varley">Jenny Varley</name>
</country>
<country name="Australie"><noRegion><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name>
</noRegion>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name>
</region>
<name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name>
<name sortKey="Jacquemier, Jocelyne" sort="Jacquemier, Jocelyne" uniqKey="Jacquemier J" first="Jocelyne" last="Jacquemier">Jocelyne Jacquemier</name>
<name sortKey="Maugard, Christine" sort="Maugard, Christine" uniqKey="Maugard C" first="Christine" last="Maugard">Christine Maugard</name>
<name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Dervijver, Marc" sort="Van Dervijver, Marc" uniqKey="Van Dervijver M" first="Marc" last="Van Dervijver">Marc Van Dervijver</name>
</region>
<name sortKey="Cornelisse, Cees J" sort="Cornelisse, Cees J" uniqKey="Cornelisse C" first="Cees J." last="Cornelisse">Cees J. Cornelisse</name>
<name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<name sortKey="Klijn, Jan G M" sort="Klijn, Jan G M" uniqKey="Klijn J" first="Jan G. M." last="Klijn">Jan G. M. Klijn</name>
<name sortKey="Meijers Heijboer, Hanne" sort="Meijers Heijboer, Hanne" uniqKey="Meijers Heijboer H" first="Hanne" last="Meijers-Heijboer">Hanne Meijers-Heijboer</name>
</country>
<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
</region>
<name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
</region>
<name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<name sortKey="Nestle Kr Mling, Carolin" sort="Nestle Kr Mling, Carolin" uniqKey="Nestle Kr Mling C" first="Carolin" last="Nestle-Kr Mling">Carolin Nestle-Kr Mling</name>
<name sortKey="Scherneck, Siegfried" sort="Scherneck, Siegfried" uniqKey="Scherneck S" first="Siegfried" last="Scherneck">Siegfried Scherneck</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name>
</noRegion>
</country>
<country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name>
</region>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="Pilotti, Silvana" sort="Pilotti, Silvana" uniqKey="Pilotti S" first="Silvana" last="Pilotti">Silvana Pilotti</name>
</region>
<name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Wagner, Teresa" sort="Wagner, Teresa" uniqKey="Wagner T" first="Teresa" last="Wagner">Teresa Wagner</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Prediction of BRCA1 status in patients with breast cancer using estroqen receptor and basal phenotype

Prediction of BRCA1 status in patients with breast cancer using estroqen receptor and basal phenotype

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